Drug accumulation

Therewere no drug accumulation at clinical dosage .

临床治疗剂量不造成体内药物蓄积。

Conclusion LR might take part in mediation of MDR in gastric cancer cells through interfering with drug accumulation and cell apoptosis .

结论LR可能通过影响药物蓄积和细胞凋亡参与对胃癌细胞MDR的调节。

Abnormal drug accumulation in multidrug resistant gastric carcinoma cells

胃癌多药耐药细胞药物积累的异常

Confocal laser scanning microscopy was performed to confirm the drug accumulation .

并利用激光共聚焦显微术确认了药物的细胞累积。

Apparent pharmacokinetic parameters of Dinggongteng Injection were determined with drug accumulation method .

用药物累积法测定丁公藤注射液的表观动力学参数。

In determining dosage regimens , it is also necessary to know the extent of drug accumulation .

在决定剂量方案时，必须知道药物在体内蓄积的程度。

Repeated administration of CZP would avoid this , but might lead to drug accumulation in the body .

氯硝西泮重复给药可有效地控制惊厥复发，但也可引起药物在体内的蓄积。

Study on Correlation between Drug Accumulation Method and Blood ─ Drug Concentration Method in Pharmacodynamic Test of Tuduranine Tablets

青藤碱制剂药动学试验中药物累积法与血药浓度法的相关性研究

But the drug accumulation was lower than the 9-NC solution in liver with no significant change in heart .

但对心脏中的药物分布没有显著性的影响，而肝脏中的药物蓄积量显著降低。

Preoperative intraperitoneal versus intravenous carboplatin chemotherapy for advanced gastric cancer , pharmacokinetics and drug accumulation study

进展期胃癌术前卡铂腹腔、静脉化疗肿瘤组织聚积浓度的比较及药代动力学研究

No evidence of drug accumulation with prolonged therapy has been noted . Therapeutic effects have been observed from 2 to 8 months after initiation of therapy .

延长治疗时间未产生明显的药物累积效应。治疗2-8个月后即可观察到治疗效果。

Conclusion PrP was highly expressed in gastric cancer cell lines SGC7901 / ADR and SGC7901 / VCR . Overexpression of PrP had certain effect on drug accumulation in gastric cancer cells .

结论朊蛋白在胃癌耐药细胞系SGC7901/ADR和SGC7901/VCR中高表达并对胃癌细胞的药物蓄积有影响。

The blood circulation time of paclitaxel in rats and mice was significantly prolonged , and the accumulation of paclitaxel in plasma , kidney , ovary & uterus and lung was increased and the drug accumulation in liver was decreased .

其可显著延长紫杉醇在大鼠和小鼠体内的血循环时间，增加其在血浆、肾、卵巢&子宫、肺中的分布量，并减少在肝脏中的药物蓄积。

Conclusions : Our studies revealed that CsA and Ver had significant reversal effects on MRP mediated MDR in human bladder carcinoma probably by decreasing drug accumulation and increasing intracellular drug efflux , and these effects were dose dependent .

结论：CsA和Ver对人膀胱癌MRP介导的MDR具有良好的逆转作用，可通过增加细胞内的药物聚集和减少外排已进入细胞内的药物起作用，这种作用存在剂量依从关系。

The intracellular drug accumulation in EJ / MRP was about 67 % of that in EJ / Vect , and intracellular drug efflux in EJ / MRP was much fast than that in EJ / VECT .

EJ/MRP细胞内的药物聚集浓度大约只有EJ/Vect细胞的67%，前者外排药物速度快于后者。

Verapamil increased the intracellular drug accumulation , and then obviously reversed the drug resistance to DNR , VCR , MIT , HHT , and VP 16 in K562 / D cells , but not in the sensitive cells ( K562 / S ) .

异搏定使K562/D细胞内药物积聚增加，明显地逆转了K562/D细胞对DNR、VCR、MIT、HHT、VP-16的耐药性，而对敏感细胞K562/S的耐药性无影响。

We need the drug can target to tumor , making the drug carrier own high accumulation in the tumor .

如果能使载体药物在肿瘤部位有高的积累，就需要一种靶向药物。

One mechanism of drug resistance is associated with over expression of multidrug resistance gene ( MDR1 ) and phenotypic expression of a trans-membrane P-glycoprotein , which acts as an efflux pump and resulting in decreased intracellular drug accumulation .

人类细胞中多药抗性基因（MDR1）编码一种p-糖蛋白，后者功能是能量依赖的跨膜药物外输泵，可降低细胞毒药物在胞内的积累。